Too many acronyms:
DMARDs, NSAIDs, and anti-TNFs, oh my!

There are a heck of a lot of acronyms that surround Psoriatic Arthritis and its related diseases! With that in mind, here's a running list of the acronyms you're likely to encounter on this blog, or in conversation with your doctor or fellow patients:

  • AS - ankylosing spondylitis. This is a related form of arthritis that can cause the spine and sacroiliac joints to fuse.1
  • CRP - C-reactive protein. This is a blood test that measures a form of protein. Elevated levels can indicate inflammation.2
  • DDX - differential diagnosis.
  • DIP - distal interphalangeal predominate. Distal interphalangeal refers to the last knuckle of the fingers or toes. DIP is the "classic" presentation of psoriatic arthritis, but not the most common.3
  • DMARD - disease modifying anti-rheumatic drug. This is a class of treatment for various forms of inflammatory arthritis. They are particularly "disease modifying" for rheumatoid arthritis patients. Methotrexate, sulfasalazine, and plaquenil are a few drugs in this class.
  • Dx - diagnosis.
  • ESR - erythrocyte sedimentation rate. This is a blood test performed to check for inflammation. It's commonly called the "sed rate".4
  • FM or FMS - fibromyalgia syndrome. Fibromyalgia is a condition that causes chronic widespread muskuloskeletal pain. It is a common misdiagnosis for psoriatic arthritis, but also occurs alongside psoriatic arthritis and other autoimmune diseases quite frequently.5
  • GP - general practitioner.
  • HLA B27 - human leukocyte antigen B27. This is a blood test for a protein found on the surface of white blood cells. HLA B27 is an indication of ankylosing spondylitis and some other spondyloarthropothies.6
  • JIA or JRA - juvenile idiopathic arthritis or juvenile rheumatoid arthritis.
  • MTX - methotrexate. This is a type of DMARD. Methotrexate is a chemotheraphy drug, but is used in smaller doses for inflammatory arthritis treatment.7
  • NPF - National Psoriasis Foundation.
  • NSAID - non-steroidal anti-inflammatory drug.
  • OA - osteoarthritis. Also known as your grandmother's arthritis.
  • PCP - primary care provider.
  • PsA - psoriatic arthritis.
  • RA - rheumatoid arthritis.
  • ReA - reactive arthritis.
  • RF - rheumatoid factor. An indication of rheumatoid arthritis, this test is rarely positive for psoriatic arthritis patients.
  • Rx - prescription.
  • SAA - Spondylitis Association of America.
  • SIJs - sacroiliac joints.
  • SpA - spondyloarthropothy or spondyloarthritis. This is the name of the group of diseases that includes psoriatic arthritis.8 
  • SSDI - social security disability insurance.
  • SSZ - sulfasalazine, a type of DMARD.
  • TB - tuberculosis. Testing for tuberculosis is required before starting TNF inhibitor treatment. Latent infections must be treated to prevent them from becoming active while taking TNF inhibitors.9
  • TNF and Anti-TNF - tumor necrosis factor. Anti-TNFs or TNF-alpha inhibitors block a portion of the immune system thought to cause inflammation. This is a common treatment for moderate to severe psoriatic arthritis.10
  • USpA - undifferentiated spondyloarthropothy. This is the diagnosis given to patients whose disease has not differentiated itself as psoriatic arthritis, ankylosing spondylitis, or another specific spondyloarthropothy.11
Please let me know if I sneak in any acronyms unexplained!


References
1. Spondylitis Association of America. (n.d.). About ankylosing spondylitis. Retrieved from 
    http://www.spondylitis.org/about/as.aspx
2. Mayo Clinic. (2011, December 16). C-reactive protein test. Retrieved from 
   http://www.mayoclinic.com/health/c-reactive-protein/my01018
3. National Psoriasis Foundation. (n.d.). Types of psoriatic arthritis. Retrieved from 
   http://www.psoriasis.org/psoriatic-arthritis/types
4. Mayo Clinic. (2010, November 19). Sed rate (erythrocyte sedimentation rate). Retrieved from 
   http://www.mayoclinic.com/health/sed-rate/MY00343
5. Buskila, D., & Sarzi-Puttini, P. (2008, January). Fibromyalgia and autoimmune diseases: the pain behind autoimmunity.
    The Israel Medical Association Journal, 10
, 77-78. Retrieved from http://www.ima.org.il/imaj/ar08jan-20.pdf?q=antipolymer

6. Dugdale, D.C. (2011, May 23). HLA-B27 antigen. In MedlinePlus Medical Encyclopedia. Retrieved from
    http://www.nlm.nih.gov/medlineplus/ency/article/003551.htm

7. Methotrexate. (2009, April 1). In MedlinePlus Medical Encyclopedia. Retrieved from 
   http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682019.html
8. Spondylitis Association of America. (n.d.). Ankylosing spondylitis & related diseases: an overview. Retrieved from
   http://www.spondylitis.org/about/overview.aspx

9. Solovic, I., Sester, M., Gomez-Reino, J.J., Rieder, H.L., Ehlers, S., Milburn, H.J., . . . Lange, C. (2010, November 1). The risk of tuberculosis related to tumour necrosis factor antagonist therapies: a TBNET consensus statement. European Respiratory Journal, 36(5), 1185-1206. Retrieved from http://erj.ersjournals.com/content/36/5/1185.full
10. Mayo Clinic. (2010, December 9). Psoriatic arthritis: treatments and drugs. Retrieved from 
   http://www.mayoclinic.com/health/psoriatic-arthritis/DS00476/DSECTION=treatments-and-drugs
11. Spondylitis Association of America. (n.d.). Undifferentiated spondyloarthropothy. Retrieved from 
   http://www.spondylitis.org/about/undif.aspx

This entry was posted on Wednesday, October 24, 2012 and is filed under . You can follow any responses to this entry through the RSS 2.0. You can leave a response.

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